Deep Learning Diagnostic and Risk-stratification for Idiopathic Pulmonary Fibrosis and Chronic Obstructive Pulmonary Disease in Digital Lung Auscultations

Status: Recruiting
Location: See location...
Intervention Type: Device, Other, Diagnostic test
Study Type: Observational
SUMMARY

Idiopathic pulmonary fibrosis (IPF), non-specific interstitial pneumonia (NSIP), and chronic obstructive pulmonary disease (COPD) are severe, progressive, irreversibly incapacitating pulmonary disorders with modest response to therapeutic interventions and poor prognosis. Prompt and accurate diagnosis is important to enable patients to receive appropriate care at the earliest possible stage to delay disease progression and prolong survival. Artificial intelligence (AI)-assisted digital lung auscultation could constitute an alternative to conventional subjective operator-related auscultation to accurately and earlier diagnose these diseases. Moreover, lung ultrasound (LUS), a relevant gold standard for lung pathology, could also benefit from automation by deep learning.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Written informed consent

• age \> 18 years old.

• patients with already-diagnosed IPF (group 1) prior to the consultation (index) date.

• patients with already-diagnosed NSIP (group 2) prior to the consultation (index) date.

• patients with already-diagnosed COPD (group 3) prior to the consultation (index) date.

• Control subjects must be followed-up at the pulmonology outpatient clinic for:

‣ obstructive sleep apnoea.

⁃ occupational lung diseases (miners, chemical workers, etc.).

⁃ pulmonary nodules (considered benign after 2 years).

Locations
Other Locations
Switzerland
Centre Hospitalier du Valais Romand
RECRUITING
Sion
Contact Information
Primary
Johan N. Siebert, MD
Johan.Siebert@hcuge.ch
+41795534072
Backup
Pierre-Olivier Bridevaux, Prof.
pierre-olivier.bridevaux@hopitalvs.ch
+41276034678
Time Frame
Start Date: 2023-04-01
Estimated Completion Date: 2024-10-31
Participants
Target number of participants: 160
Treatments
IPF patients (group 1)
Consenting adult patients \>18 years old with with already-diagnosed IPF
NSIP patients (group 2)
Consenting adult patients \>18 years old with with already-diagnosed non-specific interstitial pneumonia (NSIP)
COPD patients (group 3)
Consenting adult patients \>18 years old with with already-diagnosed chronic obstructive pulmonary disease (COPD)
Control subjects (group 4)
Consenting age-matched (+/- 2.5 years) never smokers patients with normal lung function (spirometry, lung volume and Transfer Factor for Carbon Monoxide (TLCO)) followed in the pulmonology outpatient clinic with similar quality of electronic medical records but for diseases other than the outcome of interest, namely:~1. patients with obstructive sleep apnea.~2. patients followed-up for occupational lung diseases (miners, chemical workers, etc.).~3. patients followed-up for pulmonary nodules (considered benign after 2 years).
Sponsors
Collaborators: University Hospital, Geneva, Hôpital du Valais, Swiss Federal Institute of Technology
Leads: Pediatric Clinical Research Platform

This content was sourced from clinicaltrials.gov