Immune Thrombocytopenic Purpura (ITP)Symptoms, Doctors, Treatments, Advances & More
Learn About Immune Thrombocytopenic Purpura (ITP)
Immune thrombocytopenia is a disorder characterized by a blood abnormality called thrombocytopenia, which is a shortage of blood cells called platelets that are needed for normal blood clotting.
The genetic cause of immune thrombocytopenia is unclear. This condition occurs when the body's own immune system malfunctions and attacks the body's tissues and organs (autoimmunity). Normally, the immune system produces proteins called antibodies, which attach to specific foreign particles and germs, marking them for destruction. In immune thrombocytopenia, the immune system abnormally destroys platelets and makes fewer platelets than normal. People with immune thrombocytopenia produce antibodies that attack normal platelets. The platelets are destroyed and eliminated from the body, resulting in a shortage of these cells in affected individuals. Some of these antibodies also affect the cells in the bone marrow that produce platelets (known as megakaryocytes), which leads to a decrease in platelet production, further reducing the number of platelets in the blood.
The incidence of immune thrombocytopenia is approximately 4 per 100,000 children and 3 per 100,000 adults. In adults with immune thrombocytopenia, women are affected more often than men.
Immune thrombocytopenia and other autoimmune disorders can run in families, but the inheritance pattern is usually unknown. People with a first-degree relative (such as a parent or sibling) with immune thrombocytopenia likely have an increased risk of developing the disorder themselves.
University Of Penn - Medical Group
Adam Cuker is a Hematologist practicing medicine in Philadelphia, Pennsylvania. Dr. Cuker is rated as an Elite provider by MediFind in the treatment of Immune Thrombocytopenic Purpura (ITP). He is also highly rated in 27 other conditions, according to our data. His clinical expertise encompasses Thrombocytopenia, Immune Thrombocytopenic Purpura (ITP), Adult Immune Thrombocytopenia, Splenectomy, and Knee Replacement.
CUIMC/Herbert Irving Pavilion
Cindy Neunert is a Pediatrics provider practicing medicine in New York, New York. Dr. Neunert is rated as an Elite provider by MediFind in the treatment of Immune Thrombocytopenic Purpura (ITP). She is also highly rated in 5 other conditions, according to our data. Her clinical expertise encompasses Immune Thrombocytopenic Purpura (ITP), Blood Clots, Sickle Cell Disease, Multisystem Inflammatory Syndrome in Children (MIS-C), and Splenectomy. Dr. Neunert is board certified in Pediatrics and Pediatric Hematology-Oncology. Dr. Neunert is currently accepting new patients.
Ballad Health Cancer Center
. Dr. Shipstone is rated as an Advanced provider by MediFind in the treatment of Immune Thrombocytopenic Purpura (ITP). He is also highly rated in 54 other conditions, according to our data. His clinical expertise encompasses Adult Immune Thrombocytopenia, Colorectal Cancer, Hemangioma Thrombocytopenia Syndrome, and Thrombocytopenia. Dr. Shipstone is board certified in American Board Of Internal Medicine.
Summary: This is a Phase 2, open-label, multicenter, multiple subcutaneous injection, safety and efficacy study of PF-06835375 in adult participants with primary immune thrombocytopenia (ITP). This study will focus on participants with persistent (\>3 months and ≤12 months), or chronic (\>12 months) ITP
Summary: The purpose of this study is to determine if a dose dense administration of Rituximab in newly diagnosed acute immune thrombocytopenic purpura (ITP) and determine relapse rate following this treatment. Correlative studies will be performed as outlined in the appendices. Quality of Life will be measured using the KIT as outlined in the protocol.
Published Date: June 01, 2017
Published By: National Institutes of Health