The Effects of Woodsmoke Exposure on Nasal Immune Responses to Influenza Infection in Normal Human Volunteers
Status: Recruiting
Location: See location...
Intervention Type: Biological, Other
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
This study will investigate the effects of woodsmoke (WS) exposure on human nasal mucosal immune responses to viral infection. The study tests the hypotheses that WS exposure modifies biomarkers of nasal mucosal immune function, increases in Live Attenuated Influenza Virus (LAIV) -induced nasal symptoms, and reduces mucosal antibody production.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 49
Healthy Volunteers: t
View:
• Normal lung function,
• oxygen saturation of \>94%,
• normal blood pressure,
• no respiratory symptoms on history, no abnormalities on exam, normal pulmonary function testing,
• 18-49 Years of age.
Locations
United States
North Carolina
Mary Ellen Jones
RECRUITING
Chapel Hill
Contact Information
Primary
Carole Robinette, MS
carole_robinette@med.unc.edu
919 966-5638
Backup
Chris Brooks
chris_brooks@med.unc.edu
Time Frame
Start Date: 2025-09-26
Estimated Completion Date: 2028-12-31
Participants
Target number of participants: 112
Treatments
Experimental: Wood smoke followed by LAIV
Participants will receive LAIV after a 2 hour wood smoke exposure.
Active_comparator: Wood smoke followed by Placebo
Participants will receive a LAIV placebo after a 2 hour wood smoke exposure.
Active_comparator: Clean Air followed by LAIV
Participants will receive LAIV after a 2 hour clean air exposure.
Placebo_comparator: Clean Air followed by Placebo
Participants will receive a LAIV placebo after a 2 hour clean air exposure.
Related Therapeutic Areas
Sponsors
Collaborators: National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH)
Leads: University of North Carolina, Chapel Hill