Lemborexant for Insomnia in a Patient With Dementia: An N-of-1 Trial

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY

Insomnia is a highly common, chronic disorder that is distressful for the patient but also for caregivers and can give rise to a heavy burden on the healthcare team. Sleeping aids like benzodiazepines and other sedatives (e.g., zolpidem, zopiclone) have been widely used to help treat insomnia. However, sleeping aids are also known to cause adverse drug reactions such as drowsiness and dizziness, that increases the risk of falls, driving impairment, visual impairment, cognitive impairment, and upon discontinuation may cause paradoxical rebound insomnia, delirium, and nightmares all of which exacerbate the initial insomnia. All of the negative aspects of sleeping aid use are exaggerated for older, frail adults. Some patients experience an early (young-age) onset dementia with a substantial component of insomnia. Due to the many risks associated with traditional sleeping aids they are often inappropriate in adults living with cognitive impairment and/or frailty. Lemborexant comes from a new class of medications for insomnia. Lemborexant is a dual orexin receptor antagonist that blocks the binding of wake-promoting neuropeptides orexin A and orexin B to their receptors orexin 1 receptor (OX1R) and orexin 2 receptor (OX2R), which is thought to suppress wake drive. Unlike other traditional sleeping aids, lemborexant has not shown to be significantly associated with driving impairment, rebound insomnia, or dependence/withdrawal symptoms. Also, in clinical trials it only rarely causes the types of adverse events associated with benzodiazepines and other traditional sedatives and is less often associated with discontinuations due to adverse events. While lemborexant is available on the Canadian market it is unclear how this medication will be tolerated by patients living with an early onset dementia. Understanding the effectiveness and tolerability of lemborexant will be helpful in an N of 1 trial to understand the details of effect and effectiveness in individual patients.

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: f
View:

• Identified by clinician investigator to have early-onset dementia and a significant component of insomnia.

Locations
Other Locations
Canada
Nova Scotia Health
RECRUITING
Halifax
Contact Information
Primary
Shanna C Trenaman, BScPharm, PhD
shanna.trenaman@dal.ca
19024310559
Time Frame
Start Date: 2023-12-11
Estimated Completion Date: 2028-12-11
Participants
Target number of participants: 1
Treatments
Experimental: lemborexant
The study will be an N of 1 trial over 8 weeks were treatment with lemborexant being alternated with a placebo in an ABBABAAB format.
Sponsors
Leads: Nova Scotia Health Authority

This content was sourced from clinicaltrials.gov