Effect of Lidocaine, Dexmedetomidine, Esmolol and Magnesium Use on Optic Nerve Sheath Diameter and Hemodynamic Response After Laryngoscopy: Randomized, Controlled, Double-blind Trial
Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This clinical trial aims to compare the effects of lidocaine, dexmedetomidine, esmolol, and magnesium on optic nerve sheath diameter and hemodynamic response to laryngoscopy. The participants will be patients determined to need intubation and general anesthesia for any elective surgery. Each participant will receive either lidocaine, dexmedetomidine, esmolol, magnesium, or none before anesthesia induction, according to randomization. The investigator will measure the optic nerve sheath diameter by ultrasonography before and after intubation. Researchers will compare the difference between optic nerve sheath diameter, systolic blood pressure, and heart rate before and after laryngoscopy and search for the most stable group. The trial aims to determine a general anesthesia induction protocol for patients sensitive to intracranial pressure changes reflected as optic nerve sheath diameter for easy monitoring.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:
• Patients aged 18 to 80 years who will receive endotracheal intubation for general anesthesia and have an American Society of Anesthesiologists (ASA) Physical Status classification of I to III.
Locations
Other Locations
Turkey
Haseki Trainig and Research Hospital
RECRUITING
Istanbul
Contact Information
Primary
Berna Caliskan, MD
caliskan.b@gmail.com
+905067108770
Time Frame
Start Date:2024-02-14
Estimated Completion Date:2025-07
Participants
Target number of participants:100
Treatments
Placebo_comparator: Control
In the control group, only unlabeled saline prepared in 50 ml will be administered intravenously for 10 minutes before general anesthesia induction after standard monitoring on the operating room table.
Experimental: Lidocaine
lidocaine (1.5 mg/kg) within unlabeled saline prepared in 50 ml will be administered intravenously for 10 minutes before general anesthesia induction after standard monitoring on the operating room table.
Experimental: magnesium
magnesium (20 mg/kg) within unlabeled saline prepared in 50 ml will be administered intravenously for 10 minutes before general anesthesia induction after standard monitoring on the operating room table.
Experimental: dexmedetomidine
Dexmedetomidine (1 mcg/kg) within unlabeled saline prepared in 50 ml will be administered intravenously for 10 minutes before general anesthesia induction after standard monitoring on the operating room table.
Experimental: Esmolol
Esmolol (1 mcq/kg) within unlabeled saline prepared in 50 ml will be administered intravenously for 10 minutes before general anesthesia induction after standard monitoring on the operating room table.