Diagnostic and Prognostic Biomarkers of Idiopathic Intracranial Hypertension

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY

Idiopathic intracranial hypertension (IIH) is a condition of unknown etiology, primarily affecting overweight females of childbearing age. Typically, patients experience headache and visual symptoms due to increased intracranial pressure (ICP) and papilledema. The diagnosis is difficult, and outcomes vary from no sequelae to blindness or chronic headaches. No clear prognostic indicators exist. Treatment consists of medication, weight loss, and possibly surgical intervention.There is an unmet need of defining biomarkers with prognostic or diagnostic value and defining predictors of a poor outcome. This project is a prospective, population-based cohort study including clinical data and a biobank (blood samples and cerebrospinal fluid). The investigator's primary aim is to identify biomarkers of diagnostic or prognostic value and to create a clinical IIH database. The clinical database will answer questions about patient characteristics at baseline and during follow-up, identify predictors of outcome, and help create a standardized programme for follow-up and

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Able to and willing to provide informed consent

• More than 18 years of age

• Suspicion of IIH (based on clinical evaluation by neurologist or opthalmologist)

Locations
Other Locations
Denmark
The Danish Headache Center, Department of Neurology, Rigshospitalet-Glostrup
RECRUITING
Copenhagen
Odense University Hospital, Department of Neurology
RECRUITING
Odense
Contact Information
Primary
Johanne Severinsen, M.D.
johanne.juhl.severinsen@regionh.dk
004538633553
Time Frame
Start Date: 2018-02-14
Estimated Completion Date: 2027-05-31
Participants
Target number of participants: 300
Treatments
Certain IIH or IIH-WOP
According to revised diagnostic criteria, Friedmann, 2013.
Suspected IIH
IIH is suspected, does not fulfill diagnostic criteria.
IIH ruled out
Patients in whom another diagnosis is made.
Sponsors
Leads: Danish Headache Center
Collaborators: Odense University Hospital

This content was sourced from clinicaltrials.gov