A Cohort of Maternal Vascular Malperfusion-related FGR (CoMVMFGR)
Based on a precise diagnostic standard process, through a multicenter study, we will establish a cohort focusing on placenta-mediated fetal growth restriction (FGR). Long-term follow-up will be conducted to seek predictive indicators for short-term and long-term adverse outcomes of maternal vascular malperfusion-related FGR (MVM-FGR).
• Singleton pregnancy 2. diagnosed as FGR according the delphi consensus:
⁃ Early-onset FGR(\<32 weeks) Estimated fetal weight (EFW) or abdominal circumference (AC) \< 3rd; or EFW or AC \< 10th, combined with abnormal doppler, including uterine artery pulsatility index(UtA PI) \>95th percentile, umbilical artery pulsatility index(UA PI) \>95th percentile； or umbilical artery absent end-diastolic flow (UA-AEDF) or umbilical artery reversed end-diastolic flow(UA-REDF).
⁃ Late-onset FGR(≥32 weeks) Estimated fetal weight (EFW) or abdominal circumference (AC) \< 3rd; or \>2 of the following 3 criteria:
∙ EFW or AC \<10th percentile
‣ EFW or AC crossing percentiles\>2 quartiles on growth percentiles
‣ CPR \<5th percentile or UA-Pl\>95th percentile 3.provision of signed written informed consent.