• Skeletally mature adults ≥22 and ≤80 years at the time of surgery

• Willing and able to give written informed consent and comply with study protocol and postoperative management program

• Degenerative disc disease of the lumbosacral spine in one level (L3 to S1) requiring fusion confirmed by patient history and radiographic imaging (CT/MRI/X-rays) with one or more of the following:

‣ instability (as defined by ≥3mm translation or ≥5° angulation);

⁃ osteophyte formation of facet joints or vertebral endplates;

⁃ decreased disc height, on average by \>2mm, but dependent upon the spinal level;

⁃ scarring/thickening of ligamentum flavum, annulus fibrosis, or facet joint capsule;

⁃ herniated nucleus pulposus;

⁃ facet joint degeneration/changes; and/or

⁃ vacuum phenomenon.

• Preoperative Oswestry Disability Index score ≥ 35

• Participant has not responded to conservative treatment (e.g. medications, injections, physical therapy, etc.) for a period of 6 months

• Participant is indicated for an ALIF approach to the lumbar spine