Informed Ecological Rewiring of Gut Microbiome for Dysbiosis-associated Disorders
Observational, multicenter, prospective study aimed at characterizing the gut microbiome in patients with post-infectious irritable bowel syndrome (PI-IBS) using whole genome sequencing (WGS). The study will compare microbiome composition and function between PI-IBS patients and two control groups (post-infectious subjects without irritable bowel syndrome -IBS- and healthy controls), with the goal of identifying reproducible microbial signatures and target taxa associated with disease and symptom severity.
⁃ Age ≥ 18 years old
• PI-IBS diagnosed according to Rome IV criteria (33).
• Diagnosis no earlier than 3 months before enrollment.
• Written informed consent and compliance with study procedures.
⁃ Age ≥ 18 years old
• History of acute infectious gastroenteritis \>6 months before enrollment.
• Complete recovery without persistent GI symptoms.
⁃ Age ≥ 18 years old
• Healthy donors from FMT program or blood donor program.
• No history of GI or systemic disorders.