The Collagen Factors of Rapid Progression of Keratoconus in Children: an Observational Cohort Study of the Physiological Parameter
The purpose of this observational study was to understand the differences in clinical features and mechanisms of keratoconus between children and adults. The main questions it aimed to answer as follows: (1) to understand the characteristics of keratoconus in Chinese children. (2) to observe corneal stromal cells at the cytological level using in vivo corneal laser confocal microscopy and explore the pathogenesis.
• ① Patients with keratoconus who visit the refractive clinic.
‣ The height of the posterior corneal surface is greater than 16 microns under the Pentacam corneal topography.
⁃ ARTAve \< 424 microns, ARTMax \< 339 microns.
⁃ Clinical non-inflammatory or traumatic corneal thinning and corneal astigmatism.
∙ Aged between 10 and 50 years old, no gender restrictions.
• Agree to accept and complete follow-up examinations on time. ④ I and my guardian understand and agree to participate in this clinical trial and sign the informed consent form.