The Potential of Sperm Retrieved by Micro-TESE to Fertilize Vitrified/Warmed Oocytes
Status: Unknown
Location: See all (2) locations...
Study Type: Observational
SUMMARY
Couples referred for microdissection-TESE (m-TESE) due to Klinefelter's syndrome, maturation stop in the spermatogenesis, or failed retrieval of testicular spermatozoa by conventional techniques with needle or TruCut are included. The women are stimulated with FSH in IVF protocols and the aspirated oocytes vitrified with usual applied techniques. Fresh sperm retrieved by micro-TESE are used for fertilization of the warmed oocytes. when it is not possible to obtain testicular sperm, the couples are offered fertilization with warmed oocytes. Fertilization, cleavage, implantation and pregnancy rates using sperm from the patients versus from sperm donors will be compared.
Eligibility
Participation Requirements
Sex: Male
Minimum Age: 18
Maximum Age: 100
View:
• Couples referred for micro-TESE
Locations
Other Locations
Denmark
Centre of Andrology & Fertility Clinic, Department D, Odense University Hospital
RECRUITING
Odense
Centre of Andrology & Fertility Clinic, Odense University Hospital
RECRUITING
Odense
Contact Information
Primary
Jens Fedder, MD, PhD
fedder@dadlnet.dk
+45 26820368
Time Frame
Start Date: 2015-09-01
Completion Date: 2024-06-30
Participants
Target number of participants: 100
Treatments
Study group
Couples where the men have Klinefelter's syndrome, maturation stop in the spermatogenesis or failed retrieval of testicular sperm by conventional techniques with needle or TruCut, and where testicular sperm could be obtained by micro-TESE.
Control group
Couples as in the study group, but where testicular sperm could not be obtained by micro-TESE. The oocytes therefore must be fertilized using donor sperm.
Related Therapeutic Areas
Sponsors
Leads: Odense University Hospital