The Therapeutic Effect of Curcumin in Nanogels Compared to 0.1% Fluocinolone Acetonide Oral Paste in the Management of Atrophic-Erosive Oral Lichen Planus
This randomized, double-blind clinical trial evaluates the therapeutic effects of curcumin in nanogels compared to 0.1% fluocinolone acetonide oral paste in the management of atrophic-erosive oral lichen planus (OLP). The study aims to determine whether curcumin nanogels, a natural treatment with enhanced bioavailability, are as effective and better tolerated than standard corticosteroid therapy.
• Age 18 years or older
• Ability to provide written informed consent
• Clinically and histopathologically confirmed diagnosis of erosive or atrophic oral lichen planus (OLP)
• Presence of symptoms (NRS pain score \> 0 at baseline)
• Ability to communicate and follow instructions
• Willingness to apply oral paste treatment and comply with study protocol