Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Oral Lichen Planus : A Randomized Clinical Trial
Status: Recruiting
Location: See location...
Intervention Type: Drug, Dietary supplement, Combination product
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
Bromelain, an enzyme extract derived from pineapples, has shown promise due to its anti-inflammatory and wound-healing properties. However, its efficacy in treating oral mucosal ulcers remains unexplored. This study aims to provide clinical evidence on the efficacy of bromelain for managing OLP, potentially offering a safer and more effective treatment option.
Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: f
View:
• Patients suffering from symptomatic OLP
• Patients free from any visible oral lesions other than OLP.
• Patients who agreed to take the supplied interventions.
• Patient who will agree to participate in the study.
• Patients who will accept to sign the informed consent.
Locations
Other Locations
Egypt
Cairo University
RECRUITING
Cairo
Time Frame
Start Date: 2026-02-18
Estimated Completion Date: 2026-06-15
Participants
Target number of participants: 42
Treatments
Experimental: Topical Bromelain in Orabase
Participants in this group will receive topical bromelain incorporated into an orabase.~Patients will be instructed to apply the formulation four times daily No additional topical medications will be permitted.
Active_comparator: Topical Triamcinolone Acetonide in Orabase
This group will receive topical 0.1% triamcinolone acetonide The treatment will be applied four times daily, following the same instructions and precautions as in Arm 1
Experimental: Combination of Topical Bromelain and Triamcinolone Acetonide in Orabase
Participants in this arm will be treated with a combination formulation containing both topical bromelain and 0.1% triamcinolone acetonide in orabase.~Application instructions will be identical to those in the other arms: four times daily.
Related Therapeutic Areas
Sponsors
Leads: Cairo University