Selective Internal Radiation Therapy With 90Y Resin Micropheres for Refractory Colorectal Cancer Liver Metastases - SIRT - A Translational Feasibility Study
Observational, feasibility study investigating biological aspects in patients with liver metastasis from colorectal cancer undergoing treatment with SIRT, by translational analysis of biological samples.
• Diagnosis of metastatic colorectal adenocarcinoma with liver dominant disease
• Diagnosis of liver metastasis may be made by histo- or cyto-pathology, or by clinical and imaging criteria.
• The Liver metastasis are not eligible for resection, RFA or SBRT
• All patients must be off all chemotherapeutic regimens for 14 days prior to SIRT treatment
• All patients must be off vascular endothelial growth factor inhibitors for 6 weeks prior to SIRT treatment
• Progressive disease, severe intolerance during or following all standard lines of chemo-therapy
• Eastern Cooperative Oncology Group (ECOG) performance status of 0-1
• Age 18 years or older
• Able to understand written information
• Consent to samples for translational research