• Primary HCC diagnosed by a surgeon and/or radiologist and oncologist according to the international guidelines for the management of HCC or by pathology

• Unfeasible or refusing to undergo other treatments;

• Residual normal liver volume ≥700 cc;

• With decompensated cirrhosis (Child-Pugh B or C classification);

• Without portal vein tumor thrombus;

• Eastern Cooperative Oncology Group (ECOG) score 0-1;

• Distances between tumor and normal organs (esophagus, stomach, duodenum, bowel) are more than 5 mm；

• Rejecting other therapies such as resection, liver transplantation, etc.

• Platelet count≥50 × 109/L, white blood count≥1.5 × 109/L;

• Patients infected with hepatitis B virus who are treated with adefovir or entecavir; patients infected with hepatitis C virus whose HCV DNA are negative.