Intra-tumor Injection of Drug-eluting Microspheres Loading With Chemodrug Plus Checkpoint Inhibitors and/or IL2 for Treatment of Advanced Solid Tumors
Who is this study for? Patients with advanced solid tumors
What treatments are being studied? Injection of drug-eluting microspheres into malignant tumors
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY
To study the safety and clinical effect of injection of drug-eluting microspheres with multiple chemodrug and/or protein drugs into advanced solid tumors.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 99
Healthy Volunteers: f
View:
• Solid advanced malignant tumors
• Age between18 and 99 years
• Life expectancy is greater than three months
Locations
Other Locations
China
The Second Affiliated Hospital of Guangzhou Medical University
RECRUITING
Guangzhou
Contact Information
Primary
Bingjia He, MD
464677938@qq.com
+862039195965
Backup
Zhenfeng Zhang, MD, PhD
zhangzhf@gzhmu.edu.cn
+862039195966
Time Frame
Start Date: 2020-11-01
Estimated Completion Date: 2035-11-01
Participants
Target number of participants: 100
Treatments
Experimental: Group 1: DC-Beads loading with Chemodrug/IL2/PD1/CTLA4 antibodies
Intra-tumor injection of above drugs for patients with previous treatment with PDL1 antibody and relapsed.
Experimental: Group 2: DC-Beads loading with Chemodrug/IL2/PDL1/CTLA4 antibodies
Intra-tumor injection of above drugs for patients with previous treatment with PD1 antibody and relapsed.
Experimental: Group 3: DC-Beads loading with Chemodrug/IL2/PD1/PDL1/CTLA4 antibodies
Intra-tumor injection of above drugs for patients with previous heavily treated with PD1/PDL1/CTLA4 antibodies and relapsed.
Related Therapeutic Areas
Sponsors
Leads: Second Affiliated Hospital of Guangzhou Medical University