An Evaluation Study of GPC3 Targeted Fluorescence Imaging to Guide the Surgery of Hepatocellular Carcinoma
This study is to evaluate whether intraoperative fluorescence imaging targeting GPC3 can aid improve the surgical accuracy of hepatocellular carcinoma. The main purposes of this study include: ① To raise the detection rate of hepatocellular carcinoma intraoperatively using the novel NIR-II fluorescence molecular imaging and the GPC-3 targeted fluorophore. ② To validate the safety and effectiveness of the designed GPC-3 targeted fluorophore for clinical application.
• Patients who have been diagnosed with hepatocellular carcinoma.
• Planned to receive hepatectomy.
• Liver function Child-Pugh A/B.
• GPC-3 was validated highly expressed preoperatively.
• Aged 18 to 75, and the expected lifetime is longer than 6 months.
• Approved to sign the informed consent.