• ≥18 years old, male or female

• Advanced hepatocellular carcinoma (cannot be removed or metastasized) diagnosed clinically or pathologically, at least one measurable lesion without local treatment, Child-Pugh A ;Barcelona Clinic Liver Cancer(BCLC) staging is stage B or C

• Eastern Cooperative Oncology Group (ECOG) Performance Status 0-1

• Patient has given written informed consent.

• The function of important organs meets the requirements

• Expected survival ≥12 weeks

• Non-surgical sterilization or women of childbearing age need to use a medically-accepted contraceptive (such as an intrauterine device, contraceptive or condom) during the study period and within 3 months after the end of the study treatment period.