Hepatic Arterial Infusion Chemotherapy in Combination with PD-1 Inhibitors and Lenvatinib for Intermediate and Advanced Hepatocellular Carcinoma After the Failure of Systemic Therapy Recommended by BCLC
The purpose of this study is to evaluate the safety and efficacy of hepatic arterial infusion chemotherapy (HAIC) in combination with PD-1 inhibitors and Lenvatinib in patients with intermediate or advanced-stage hepatocellular carcinoma (HCC) after failure of systemic therapy recommended by BCLC.
• Has a diagnosis of HCC confirmed by radiology, histology, or cytology;
• Barcelona Clinic Liver Cancer (BCLC) stage C with the presence of portal vein tumor thrombus;
• Has received previous systemic therapy recommended for HCC by BCLC, and the systemic therapy failed;
• Both PD-1inhibitors and Lenvatinib patients received only include marketed drugs but are not limited to HCC approval;
• HAIC was performed after the first PD-1 inhibitor/ Lenvatinib treatment or before treatment;
• Received at least 2 cycles of HAIC；
• Has repeated measurable intrahepatic lesions;
• Child-Pugh class A or B.