• Clinical diagnosis of primary HCC.

• Age between 18 and 75 years;

• The maximum tumor size ≥10 cm;

• Intermediate-advanced huge HCC, advanced HCC with PVTT type I-III

• limited metastases (≤5).

• Child-Pugh class A or B;

• Eastern Cooperative Group performance status (ECOG) score of 0-1;

• Hemoglobin ≥ 8.5 g/dL Total bilirubin ≤ 30mmol/L Serum albumin ≥ 32 g/L ASL and AST ≤ 5 x upper limit of normal Serum creatinine ≤ 1.5 x upper limit of normal INR ≤ 1.5 or PT/APTT within normal limits Absolute neutrophil count (ANC) \>1,500/mm3

• Prothrombin time ≤18s or international normalized ratio \< 1.7.