Atezolizumab and Bevacizumab With Stereotactic Body Radiotherapy for Advanced Hepatocellular Carcinoma

Status: Recruiting
Location: See location...
Intervention Type: Radiation
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

To determine the efficacy and safety of atezolizumab-bevacizumab combination therapy plus stereotactic body radiotherapy(SBRT) in patients with advanced hepatocellular carcinoma, Subjects will start SBRT for one or more primary cancers and/or metastatic lesions and no more than 5 sites within two month before and after the start date of atezolizumab-bevacizumab combination therapy. In this study, it is expected to improve the treatment response rate of atezolizumab-bevacizumab therapy, which is currently first-line chemotherapy but has a low treatment response rate.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 19
Maximum Age: 80
Healthy Volunteers: f
View:

• Age 19 to 80 years old

• Liver function Child-Pugh class A

• ECOG 0-1

• Patient clinically or pathologically diagnosed with hepatocellular carcinoma

• Advanced hepatocellular carcinoma that is inoperable

• Satisfies the dose limits for normal organs and lesions of an appropriate size to be included in the scope of radiotherapy.

Locations
Other Locations
Republic of Korea
Yongin Severance Hospital
RECRUITING
Yongin-si
Contact Information
Primary
Hwakyung BYUN, Phd
hkbyun05@yuhs.ac
007981072098955
Time Frame
Start Date: 2024-05-28
Estimated Completion Date: 2028-03-27
Participants
Target number of participants: 33
Treatments
Experimental: Patients with advanced hepatocellular carcinoma
Patients indicated for the first-line atezolizumab-bevacizumab combination therapy are the primary subjects, and those voluntarily agree to the clinical trial after explanation of the study, are enrolled in the study.
Related Therapeutic Areas
Sponsors
Leads: Yonsei University

This content was sourced from clinicaltrials.gov