Atezolizumab and Bevacizumab With Stereotactic Body Radiotherapy for Advanced Hepatocellular Carcinoma
To determine the efficacy and safety of atezolizumab-bevacizumab combination therapy plus stereotactic body radiotherapy(SBRT) in patients with advanced hepatocellular carcinoma, Subjects will start SBRT for one or more primary cancers and/or metastatic lesions and no more than 5 sites within two month before and after the start date of atezolizumab-bevacizumab combination therapy. In this study, it is expected to improve the treatment response rate of atezolizumab-bevacizumab therapy, which is currently first-line chemotherapy but has a low treatment response rate.
• Age 19 to 80 years old
• Liver function Child-Pugh class A
• ECOG 0-1
• Patient clinically or pathologically diagnosed with hepatocellular carcinoma
• Advanced hepatocellular carcinoma that is inoperable
• Satisfies the dose limits for normal organs and lesions of an appropriate size to be included in the scope of radiotherapy.