• Able and willing to provide a written informed consent

• ≥ 18 years old, both male and female

• Unresectable locally advanced or metastatic HCC confirmed by histopathologically/cytologically

• At least one measurable lesion based on RECIST v1.1 criteria

• Barcelona clinic liver cancer: Stage B or C

• No previous systemic antitumor therapy for HCC

• ECOG PS of 0-1

• Child-Pugh score of A or B7

• Expected survival period ≥ 12 weeks

⁃ Adequate organ function

⁃ Blood pregnancy negative (women of childbearing age) and non-breastfeeding, effective contraception