[68Ga]Ga-PSMA PET/CT in Hepatocellular Carcinoma: Impact of Multiparametric Dynamic Whole-body Imaging and Kinetic Modeling.
The purpose of this study is to evaluate the use of multiparametric dynamic whole-body \[68Ga\]Ga-PSMA PET/CT imaging in newly diagnosed HCC patients or in HCC patients with recent suspicion of refractory, residual, or recurrent disease.
• Provided written informed consent
• Patient aged ≥ 18 years
• For cohort A: patient with HCC histologically proven or who meet radiological criteria and are scheduled for biopsy For cohort B: patient with known HCC requiring a new diagnostic imaging workup for suspected refractory, residual or recurrent disease
• Presence of at least one morphological evaluable lesion according to mRECIST 1.1 using contrast CT/MRI
• Patient must have an ECOG (Eastern Cooperative Oncology Group) performance status of 0 to 2
• Patient who are Child-Pugh A
• Patient must have a life expectancy ≥ 6 months as determined by the study investigator
• Patient affiliated to or beneficiary of the National Health Service
• Consent to practice double-barrier contraception after \[68Ga\]Ga-PSMA injection (6 months of contraception for women study participant and their partners, and 3 months for men study participant and their partners)