Usability and Clinical Effectiveness of an Interpretable Deep Learning Framework (VAE-MILP) Using Counterfactual Explanations and Layerwise Relevance Propagation Framework for Post-Hepatectomy Liver Failure Prediction

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

The goal of this in-silico clinical trial is to learn about the usability and clinical effectiveness of an interpretable deep learning framework (VAE-MLP) using counterfactual explanations and layerwise relevance propagation for prediction of post-hepatectomy liver failure (PHLF) in patients with hepatocellular carcinoma (HCC). The main questions it aims to answer are: * To investigate the usability of the VAE-MLP framework for explanation of the deep learning model. * To investigate the clinical effectiveness of VAE-MLP framework for prediction of post-hepatectomy liver failure in patients with hepatocellular carcinoma. In the usability trial the clinicians and radiologists will be shown the counterfactual explanations and layerwise relevance propagation (LRP) plots to evaluate the usability of the framework. In the clinical trial the clinicians and radiologists will make the prediction under two different conditions: with model explanation and without model explanation with a washout period of at least 14 days to evaluate the clinical effectiveness of the explanation framework.

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: f
View:

• patients with treatment-naive and resectable HCC;

• performance status Eastern Cooperative Oncology Group (PS) score 0-1.

Locations
Other Locations
China
The First Affiliated Hospital of Sun Yat-Sen University
RECRUITING
Guangzhou
Contact Information
Primary
Xian Zhong
x.zhong@maastrichtuniversity.nl
86-13632460144
Time Frame
Start Date: 2023-12-10
Estimated Completion Date: 2024-03-15
Participants
Target number of participants: 80
Treatments
Patients with HCC
Patients who underwent curative liver resection for HCC in the First Affiliated Hospital of Sun Yat-Sen University in China.
Related Therapeutic Areas
Sponsors
Collaborators: First Affiliated Hospital, Sun Yat-Sen University
Leads: Maastricht University

This content was sourced from clinicaltrials.gov