Effect of Perioperative Oral Rifaximin on Early Graft Dysfunction in Adult Living Donor Liver Transplant: An Open Label Randomized Control Trial

Status: Recruiting
Location: See location...
Intervention Type: Other, Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Liver transplantation has been a lifesaving treatment for individuals with end stage liver disease and acute liver failure. However, initial poor function of a liver allograft after liver transplantation, termed early graft dysfunction (EGD), has been associated with increased allograft loss or mortality after transplantation. EGD in LDLT is multifactorial. Factors affecting EGD are GRWR, ischemia reperfusion injury, recipient metabolic demand, graft quality, graft inflow and outflow. Studies shows that the incidence of EGD is 15-38%. It is associated with increased allograft loss \& mortality. Rifaximin is an antibiotic that reduces EGD by 50% as shown by 2 studies but this study was done in DDLT setting and rifaximin was given in the pretransplant group. In this investigators will study the effect of perioperative oral rifaximin on early graft dysfunction in adult living donor liver transplant.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• All recipients (adults) undergoing living donor liver transplant in ILBS.

Locations
Other Locations
India
Insitute of Liver and Biliary Sciences
RECRUITING
New Delhi
Contact Information
Primary
Tapan Kumar Pradhan, MS
tapan.ravi94@gmail.com
9970189001
Backup
Nilesh Sadashiv Patil, MCh
dr.nils.p@gmail.com
01146300000
Time Frame
Start Date: 2024-12-01
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 100
Treatments
Experimental: Rifaximin+SOC
Preoperative Rifaximin supplementation 550 mg twice daily from preoperatively 2 weeks to post op POD 1 to 7 SOC (Standard of care) means both group will recieve similar post of care which is standard protocol at ILBS.
Active_comparator: Non Rifaximin + SOC
SOC (Standard of care) means both group will recieve similar post of care which is standard protocol at ILBS.
Related Therapeutic Areas
Sponsors
Leads: Institute of Liver and Biliary Sciences, India

This content was sourced from clinicaltrials.gov