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Effect of Preoperative Oral Carbohydrate Loading on Postoperative Outcomes in Liver Transplant Patients: A Randomized, Placebo-Controlled Trial

Status: Recruiting
Location: See location...
Intervention Type: Dietary supplement
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The aim of the study is to evaluate the effect of preoperative oral carbohydrate loading on postoperative outcomes in liver transplant recipients. The results of this study may contribute to improving recovery after liver transplantation and shortening postoperative hospital stay in these patients. Participants will be randomly assigned to either the study group or the control group. Patients assigned to the study group will receive 400 mL of a carbohydrate beverage (Nutricia preOp®), to be consumed up to 2 hours before the anesthesia induction. Patients assigned to the control group will receive 400 mL of a placebo administered in an identical manner as in the study group. Participants will not be informed which group they have been assigned to. In the postoperative period, routine laboratory and imaging tests will be performed, and their results will be used to assess the effects of the intervention. Follow-up of the patient's clinical course is planned for up to 30 days after surgery. The schedule of follow-up visits will not differ from standard clinical practice.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• age ≥ 18 years

• elective liver transplantation at the Department of General, Transplant, and Liver Surgery, Medical University of Warsaw

• grafts from brain-dead donors

• MELD score \<35

Locations
Other Locations
Poland
Department of General, Transplant, and Liver Surgery, Medical University of Warsaw
RECRUITING
Warsaw
Contact Information
Primary
Maciej Krasnodębski, MD, PhD
maciej.krasnodebski@wum.edu.pl
+48225992459
Backup
Eryk Siedlecki
eryk.siedlecki@wum.edu.pl
Time Frame
Start Date: 2026-05-27
Estimated Completion Date: 2028-08
Participants
Target number of participants: 434
Treatments
Experimental: Preoperative Oral Carbohydrate Loading Group
Participants will receive 400 mL of a preoperative oral carbohydrate drink (Nutricia preOp®), with intake completed 2 hours prior to anesthesia induction.
Placebo_comparator: Placebo Group
Participants will receive 400 mL of a water-based, sensory-similar placebo drink, with intake completed 2 hours prior to anesthesia induction. The placebo contains a low concentration of sugar for flavoring to mimic the taste of the carbohydrate drink.
Related Therapeutic Areas
Sponsors
Leads: Medical University of Warsaw

This content was sourced from clinicaltrials.gov