Cerebral Perfusion Variation During Blood Pressure Changes Under General Anesthesia: Relationship Between Transcranial Doppler, Frontal EEG, and Cerebral Oximetry: a Prospective Observational Study

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Observational
SUMMARY

The risk associated with arterial hypotension during general anesthesia for surgery has been demonstrated , but the threshold at which consequences for perfusion of one or more organs appear varies according to the mechanism of hypotension, associated abnormalities (HR, cardiac output, and oxygen transport), and the patient's terrain. Currently, a mean arterial pressure greater than 60 mm Hg and a reduction of less than 30-50% from the value measured before general anesthesia are commonly used treatment thresholds to ensure good perfusion of all organs. Normally, cerebral blood flow is auto-regulated, which allows cerebral blood flow to adapt to oxygen requirements and to different levels of blood pressure, both high and low. However, this protective mechanism may fail for a degree of hypotension that depends on several factors such as the age or vascular status of the patient. The aim of the study is to measure non-invasively, easily and reliably the variations of cerebral perfusion in patients with and without cardiovascular risk factors during controlled variations performed during routine care to set the blood pressure level within the recommended safety standards during general anesthesia. What is the target level of blood pressure tolerable for a patient under general anesthesia? Is there a simple and non-invasive way to measure the level of cerebral blood flow autoregulation and especially its adequacy to the brain's oxygen needs?

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patients of legal age (≥ 18 years)

• Eligible for scheduled surgery at Lariboisière Hospital

• Informed patient who has expressed no objection to participating in this research

Locations
Other Locations
France
Joaquim MATEO
RECRUITING
Paris
Contact Information
Primary
Joaquim MATEO, MD
joaquim.mateo@aphp.fr
+33 (0)149958374
Backup
Fabrice VALLEE, MD, PhD
fabrice.vallee@gmail.com
+33 (0)1 49 95 80 71
Time Frame
Start Date: 2023-07-20
Estimated Completion Date: 2025-08
Participants
Target number of participants: 100
Treatments
General anesthesia
Patients undergoing surgery under general anesthesia with an intravenous anesthesia protocol with a concentration target (Orchestra® Base Primea - Fresenius Kabi France), a vasopressor support by norepinephrine and blood pressure optimisation.
Related Therapeutic Areas
Sponsors
Collaborators: M3DISIM, INSERM UMR-942, Paris, France
Leads: Assistance Publique - Hôpitaux de Paris

This content was sourced from clinicaltrials.gov