Does Induction of Anesthesia with Target-controlled Propofol Infusion Reduce the Risk of Post-induction Hypotension in High-risk Patients?
Status: Recruiting
Location: See location...
Intervention Type: Drug, Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The purpose of this study is to compare the risk of hypotension following induction of anesthesia in high-risk patients (American Society of Anesthesiologists risk scores III and IV) using target-controlled infusion (TCI) of propofol versus standard manual induction of anesthesia. Our previously published study compared TCI and manual induction of anesthesia in a general patient population and found that hypotension developed less with TCI induction. This study is a continuation of the other study and will be conducted in high-risk patients.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 100
Healthy Volunteers: f
View:
• Patients with the American Society of Anesthesiology physical status 3-4
• Underwent major elective surgery
• Required intra-arterial blood pressure monitoring before induction.
Locations
Other Locations
Turkey
Acibadem Altunizade Hospital
RECRUITING
Istanbul
Contact Information
Primary
Serap A Aktas Yildirim, MD
serapaktas79@yahoo.com.tr
+905325605077
Backup
Zeynep Tugce Sarikaya, M.D.
lredzheb@gmail.com
Time Frame
Start Date: 2024-08-30
Estimated Completion Date: 2025-06-30
Participants
Target number of participants: 200
Treatments
Active_comparator: Patients who were assigned to have manual anesthesia induction group with propofol
Patients who were assigned to have a manual anesthesia induction group, propofol was administered 1-2 mg/kg in 1-2 minutes to achieve a level of hypnosis measured by bispectral index ( BIS ) of 35-60
Active_comparator: Patients who were assigned to have target controlled infusions ( TCI) induction with propofol
Patients who were assigned to have TCI induction had the target effect site concentration (Ce) of propofol (Ce) set at 1 μg ml-1 using the Schneider model and subsequently modified to achieve and maintain a level of hypnosis measured by BIS of 35-55
Related Therapeutic Areas
Sponsors
Leads: Acibadem University