Impact of Reduced Intraoperative Norepinephrine Requirements Via Processed Electroencephalography-Guided General Anesthesia on Patient Outcomes After Major Abdominal Surgeries
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study aims to evaluate whether the reduction in the amount of intraoperative norepinephrine required to prevent hypotension, facilitated by processed electroencephalography (pEEG) -guided general anesthesia, will lead to a decrease in postoperative complications, particularly acute kidney injury (AKI).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: f
View:
• Patients scheduled for major abdominal surgery lasting more than 2 hours under general anesthesia.
• American Society of Anesthesiologists Physical Status (ASA) score I-III.
• Age range of 18-70 years.
• Both male and female patients.
Locations
Other Locations
Egypt
Assiut University Hospitals
RECRUITING
Asyut
Contact Information
Primary
Walaa H Mohamed, Assistant Lecturer
walaa95.hamdy@gmail.com
+201061403338
Backup
Mostafa S Abbas, Professor
mostafasamy@aun.edu.eg
+201003060187
Time Frame
Start Date: 2025-02-01
Estimated Completion Date: 2027-01-01
Participants
Target number of participants: 162
Treatments
Active_comparator: pEEG-Guided General Anesthesia Group
Depth of anesthesia will be managed based on pEEG monitoring using Entropy with a target range of 40-60.
Placebo_comparator: Non-pEEG-Guided Anesthesia (Standard Care Group) with blinded pEEG monitoring
Depth of anesthesia will be managed based on clinical judgment, informed by clinical perception and vital signs.
Related Therapeutic Areas
Sponsors
Leads: Assiut University