Effect of Ephedrine and Norepinephrine on Fetal Acidosis During Cesarean Section Under Spinal Anesthesia: A Prospective, Randomized Controlled Trial

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY

This study compares the effects of two medications, ephedrine and norepinephrine, on the baby (fetus) when used to treat low blood pressure (hypotension) during cesarean section under spinal anesthesia. Hypotension is a common side effect during spinal anesthesia, and it can affect the blood flow to the baby. Both medications are commonly used to manage this condition. The goal of the study is to determine which medication is more effective and safer for the baby, by measuring the pH level in the umbilical artery after birth. The study will also examine maternal blood pressure, heart rate, and the baby's Apgar scores.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 45
Healthy Volunteers: f
View:

• Pregnant women aged between 18 and 45 years

• Singleton pregnancy at ≥ 37 weeks of gestation

• Scheduled for elective cesarean section under spinal anesthesia

• ASA (American Society of Anesthesiologists) physical status classification I or II

• Ability to understand and sign the informed consent form

Locations
Other Locations
Turkey
SBÜ Gazi Yaşargil Eğitim ve Araştırma Hastanesi
RECRUITING
Diyarbakır
Contact Information
Primary
Mehmet ÖZKILIÇ, Anesthesiology and Intensive Care Specialist, MD
mehmet.ozkilic@saglik.gov.tr
+905070068313
Time Frame
Start Date: 2025-09-01
Estimated Completion Date: 2025-12-15
Participants
Target number of participants: 100
Treatments
Active_comparator: Ephedrine Group
Participants in this group will receive intravenous bolus doses of ephedrine (5-10 mg) to manage spinal anesthesia-induced hypotension during cesarean section.
Experimental: Norepinephrine Group
Participants in this group will receive intravenous bolus doses of norepinephrine (5-10 µg) to manage spinal anesthesia-induced hypotension during cesarean section.
Related Therapeutic Areas
Low Blood Pressure
Sponsors
Leads: mehmet özkılıç

This content was sourced from clinicaltrials.gov

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