In Cesarean Sections, is the Length of the Thoracolumbar Vertebral Column Applicable for Determining the Dosage of Bupivacaine in Spinal Anesthesia?

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Our hypothesis is that the bupivacaine dose determined according to the thoracolumbar vertebral body length (VBL) is more effective in achieving a lower hypotension rate during spinal anesthesia for cesarean delivery than the dose usually adjusted based on height and weight. The VBL measurements were determined from the midpoint of C7 to the tuffier line L4 spinous process. Method: Patients ranging in height from 150 to 170 were randomly assigned to either Group 1 (0.2 mg of 0.5% hyperbaric bupivacaine per cm VBL or Group 2 (height-adjusted dose of 0.5% hyperbaric bupivacaine based on a minimum dose of 0.065 mg/cm according to height) or Group 3 (height-adjusted dose of 0.5% hyperbaric bupivacaine based on a minimum height-adjusted dose of 0.065 mg/cm).

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 45
Healthy Volunteers: t
View:

• American Society of Anesthesiologists (ASA) Class II

• Having regular antenatal visits

• Singleton pregnancy at ≥37 weeks of gestation

• Pregnant women aged 18-45 -

Locations
Other Locations
Turkey
Kudret Doğru
RECRUITING
Kayseri
Contact Information
Primary
Kudret Dr Dogru, Prof. Dr.
kdogru@erciyes.edu.tr
+905334735112
Backup
Ozlem Oz Oz Gergin, Ass. Pr. Dr.
ozgergin@erciyes.edu.tr
+905332466396
Time Frame
Start Date: 2025-05-20
Estimated Completion Date: 2026-05-01
Participants
Target number of participants: 285
Treatments
Active_comparator: Group VBL (Vertebral body length) received 0.2 mg x VBL cm of %0.5 hyperbaric bupivacaine,
Patients in Group VBL (Vertebral body length) received 0.2 mg x VBL cm of 0.5% hyperbaric bupivacaine
Active_comparator: Group FD (fixed dose) received a volume of 0.5% hyperbaric bupivacaine based on a dose calculated ac
Group FD (fixed dose) received a volume of 0.5% hyperbaric bupivacaine based on a dose calculated according to the patient's height 0.065 mg/cm
Active_comparator: Group AD (adjusted dosage) got intrathecal heavy bupivacaine (0.5%) tailored to the patient's height
Group AD (adjusted dosage) got intrathecal heavy bupivacaine (0.5%) tailored to the patient's height and weight
Related Therapeutic Areas
Sponsors
Leads: TC Erciyes University

This content was sourced from clinicaltrials.gov