Impact of Sub-anesthetic Dose of Ketamine in the Prevention of Post Spinal Hypotension in Patients Undergoing Orthopedic Surgeries
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This randomized, double-blind, controlled clinical trial investigates the efficacy of a sub-anesthetic dose of ketamine (0.5 mg/kg IV) in preventing post-spinal hypotension in patients undergoing elective orthopedic surgeries under spinal anesthesia. The study compares ketamine with placebo (normal saline) in terms of blood pressure stability and incidence of hypotensive episodes following spinal anesthesia.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Patients American Society of Anesthesiologists Physical Status (ASA) I to II undergoing orthopedic surgeries under spinal anesthesia.
• Both Sexes.
• Patients aged equal to or above 18 years.
• Body mass index \<35 kg/m2
• Duration of operation from 1 hour to 3 hours
Locations
Other Locations
Egypt
Ain Shams University Hospitals
RECRUITING
Cairo
Contact Information
Primary
Amira G Abdelmoniem Abdalla, M.B.B.Ch.
am.ga.ab.ab.mo@gmail.com
+201277719693
Backup
Mohammed S Shorbagy, M.D
+201069961005
Time Frame
Start Date: 2025-06-01
Estimated Completion Date: 2025-11-01
Participants
Target number of participants: 30
Treatments
Experimental: Ketamine Group
Patients receive crystalloid preloading of 15ml/kg (Ringer's lactate) +the sub-anesthetic dose of ketamine of 0.5 mg/kg IV added to the first bottle of ringer for blinding over 20 min before the spinal injection.
Placebo_comparator: Control Group
Patients receive a crystalloid preloading of 15 ml/kg (Ringer's lactate)+ 0.5 mg/kg IV of Normal Saline added to the first bottle of ringer for blinding, over 20 min before the spinal injection.
Related Therapeutic Areas
Sponsors
Leads: Ain Shams University