The Effect of Ciprofol on Intraoperative Hypotension in Elderly Patients Receiving Renin-angiotensin System Inhibitors: a Prospective, Randomized Controlled Trial

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY

The prevention of intraoperative hypotension could reduce postoperative organ injury and mortality, particularly in elderly patients receiving long-term renin-angiotensin system inhibitors. Previous meta-analyses suggest that ciprofol, a novel intravenous anesthetic agent, may provide improved hemodynamic stability compared to propofol; however, its precise effects on perioperative hemodynamics remain unclear. The study will assess whether ciprofol improves perioperative hemodynamic stability in elderly patients receiving renin-angiotensin system inhibitors.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 65
Healthy Volunteers: f
View:

• Patients undergoing elective abdominal surgery under general anesthesia

• Duration of surgery exceeding 2 hours

• Patients receiving long-term renin-angiotensin system inhibitor therapy (\>3 months prior to surgery)

• Age ≥ 65 years

• ASA classification II-III

• Informed consent was obtained from patients or their guardians

Locations
Other Locations
China
The Second Affiliated Hospital of Zhejiang University anesthesiology department
RECRUITING
Hangzhou
Contact Information
Primary
Min Yan
zryanmin@zju.edu.cn
0571-87783759
Time Frame
Start Date: 2025-04-10
Estimated Completion Date: 2026-04-10
Participants
Target number of participants: 140
Treatments
Experimental: Ciprofol Group
General anesthesia induction and maintenance were performed using ciprofol.
Placebo_comparator: Propofol group
General anesthesia induction and maintenance were performed using propofol.
Related Therapeutic Areas
Sponsors
Leads: Second Affiliated Hospital, School of Medicine, Zhejiang University

This content was sourced from clinicaltrials.gov