The Effect of Ciprofol on Intraoperative Hypotension in Elderly Patients Receiving Renin-angiotensin System Inhibitors: a Prospective, Randomized Controlled Trial
The prevention of intraoperative hypotension could reduce postoperative organ injury and mortality, particularly in elderly patients receiving long-term renin-angiotensin system inhibitors. Previous meta-analyses suggest that ciprofol, a novel intravenous anesthetic agent, may provide improved hemodynamic stability compared to propofol; however, its precise effects on perioperative hemodynamics remain unclear. The study will assess whether ciprofol improves perioperative hemodynamic stability in elderly patients receiving renin-angiotensin system inhibitors.
• Patients undergoing elective abdominal surgery under general anesthesia
• Duration of surgery exceeding 2 hours
• Patients receiving long-term renin-angiotensin system inhibitor therapy (\>3 months prior to surgery)
• Age ≥ 65 years
• ASA classification II-III
• Informed consent was obtained from patients or their guardians