Predictive Role of Echocardiographic Parameters for Hemodynamic Support Needs During Initiation of Continuous Venovenous Hemodiafiltration in ICU Patients

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

This prospective observational study aims to evaluate whether transthoracic echocardiographic parameters-Left Ventricular Outflow Tract Velocity-Time Integral (LVOT VTI), Mitral Annular Plane Systolic Excursion (MAPSE), Tricuspid Annular Plane Systolic Excursion (TAPSE), S' wave velocity, and E/e' ratio-can predict hemodynamic instability at the initiation of sustained low-efficiency daily dialysis (SVVHDF) in intensive care unit (ICU) patients. The study will include adult patients requiring SVVHDF, and echocardiographic measurements will be performed prior to dialysis. The primary outcome is the need for hemodynamic support (vasopressors/inotropes or fluid resuscitation) or development of hypotension within the first 60 minutes of dialysis. The study aims to identify which of these parameters best predict the need for hemodynamic intervention, with the goal of supporting individualized dialysis planning and safer fluid management in critically ill patients.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age ≥18 years

• Admission to the intensive care unit (ICU)

• Clinical indication for initiation of continuous veno-venous hemodiafiltration (CVVHDF)

• Ability to obtain adequate transthoracic echocardiographic (TTE) images prior to CVVHDF

• Written informed consent obtained from the patient's legal representative

Locations
Other Locations
Turkey
Health Science University İstanbul Kanuni Sultan Süleyman Education and Training Hospital
RECRUITING
Istanbul
Time Frame
Start Date: 2025-06-23
Estimated Completion Date: 2026-06-15
Participants
Target number of participants: 40
Treatments
CVVHDF Candidates in ICU
Adult intensive care unit (ICU) patients who are scheduled to undergo continuous veno-venous hemodiafiltration (CVVHDF). All participants will undergo transthoracic echocardiographic evaluation prior to dialysis initiation. Hemodynamic parameters will be monitored for 60 minutes following the start of CVVHDF to assess the development of hypotension or the need for vasopressor, inotropic, or fluid support.
Related Therapeutic Areas
Sponsors
Leads: Kanuni Sultan Suleyman Training and Research Hospital

This content was sourced from clinicaltrials.gov