Hypotension Prediction Index Guided Prevention of Intradialytic Hypotension During Intermittent Renal Replacement Therapy in Intensive Care Units
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This single-center, crossover randomized controlled trial (HyPIR-ICU) investigates whether a Hypotension Prediction Index (HPI)-guided management strategy can reduce intradialytic hypotension (IDH) during prolonged intermittent renal replacement therapy (PIRRT) in critically ill patients. All participants must have an indwelling arterial catheter for continuous hemodynamic monitoring.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Adults \>18 years old
• Diagnosed with acute kidney injury (AKI) or end-stage kidney disease (ESKD)
• Admitted to medical ICU
• Scheduled for PIRRT
• Have an indwelling arterial catheter
Locations
Other Locations
Thailand
Division of Nephrology, Faculty of Medicine, Chulalongkorn University
RECRUITING
Bangkok
Contact Information
Primary
Nattapakorn Mai-on
nattapakorn.m@gmail.com
66970051116
Backup
Nuttha Lumlertgul
nlumlertgul@gmail.com
66855788949
Time Frame
Start Date: 2025-10-10
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 46
Treatments
Experimental: HPI first
Arm A: HPI-guided management during first PIRRT → standard care in second session
Experimental: Standard of care first
Arm B: Standard care during first PIRRT → HPI-guided management in second session
Related Therapeutic Areas
Sponsors
Leads: Chulalongkorn University