Effect of Fasting on Hypoglycemic Counterregulation in Type 1 Diabetes
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Iatrogenic hypoglycemia is still considered to be the number one barrier to effective glycemic control in patients with type 1 diabetes (T1D). In a previous study, it was observed in people without diabetes that fasting can be detrimental to the hormonal and hepatic responses to insulin-induced hypoglycemia. In the experiments described herein, the impact fasting has on hypoglycemic counterregulation in people with T1D will be determined.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 45
Healthy Volunteers: f
View:
• males and females of any race or ethnicity
• non-obese (BMI \< or = to 30)
• have a diagnosis of type 1 diabetes
• C-peptide negative
Locations
United States
Ohio
University of Cincinnati
RECRUITING
Cincinnati
Contact Information
Primary
Jason Winnick, PhD
jason.winnick@uc.edu
513-558-4437
Backup
Alyssa Randolph
Randolas@ucmail.uc.edu
513-558-3427
Time Frame
Start Date: 2019-10-10
Estimated Completion Date: 2024-12-31
Participants
Target number of participants: 10
Treatments
Experimental: Fasting
Subjects will remain fasted prior to insulin-induced hypoglycemia.
Experimental: Feeding
Subjects will eat a normal breakfast and lunch prior to insulin-induced hypoglycemia.
Related Therapeutic Areas
Sponsors
Leads: University of Cincinnati