Mechanisms of Hypoglycemia Associated Autonomic Dysfunction, Differing Levels of Hypoglycemia
Who is this study for? Patients with Hypoglycemia
What treatments are being studied? Glucose Clamp
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Device
Study Type: Interventional
Study Phase: Early Phase 1
SUMMARY
Hypoglycemia can produce a spectrum of pro-inflammatory and pro-atherothrombotic changes. To date no studies appear to have investigated the effects of differing levels of hypoglycemia on the vasculature and pro-atherothrombotic balance during hypoglycemia in healthy man. The specific aim of our study will be to determine the effects of differing levels of hypoglycemia on in-vivo vascular biologic mechanisms in a healthy population.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 55
Healthy Volunteers: t
View:
• • Body mass index \>21kg · m-2
Locations
United States
Maryland
University of Maryland, Baltimore
RECRUITING
Baltimore
University of Maryland, Baltimore
RECRUITING
Baltimore
Contact Information
Primary
Maka Siamashvili, MD
msiamashvili@som.umaryland.edu
410-706-5623
Time Frame
Start Date: 2015-07
Estimated Completion Date: 2026-12
Participants
Target number of participants: 32
Treatments
Experimental: 90 mg/dl glucose clamp
Glucose clamp intervention of 90 mg/dl maintained for 90 minutes.
Experimental: 70 mg/dl glucose clamp
Glucose clamp intervention of 70 mg/dl maintained for 90 minutes.
Experimental: 60 mg/dl glucose clamp
Glucose clamp intervention of 60 mg/dl maintained for 90 minutes.
Experimental: 50 mg/dl glucose clamp
Glucose clamp intervention of 50 mg/dl maintained for 90 minutes.
Related Therapeutic Areas
Sponsors
Collaborators: Vanderbilt University
Leads: University of Maryland, Baltimore