Effect of Protein Supplementation in Hospitalized Patients With Hyponatremia Due to the Syndrome of Inappropriate Antidiuresis - a Monocentric Randomized Open-label Pragmatic Active-controlled Trial - the TREASUREx Trial
Status: Recruiting
Location: See location...
Intervention Type: Behavioral, Dietary supplement
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The goal of this study is to assess the impact of protein supplementation on hyponatremia caused by the syndrome of inappropriate antidiuresis during hospitalization.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Adult patients with confirmed SIAD during the hospital stay or at screening, defined by:
• Plasma sodium concentration \<135 mmol/L
• Plasma osmolality \<300 mOsm/kg
• Urine osmolality \>100 mOsm/kg
• Urine sodium concentration \>30 mmol/L
• Clinical euvolemia (no signs of hypovolemia or hypervolemia)
Locations
Other Locations
Switzerland
University Hospital Basel
RECRUITING
Basel
Contact Information
Primary
Mirjam Christ-Crain, Prof. MD
mirjam.christ-crain@usb.ch
+41 61 328 70 80
Backup
Cemile Bathelt
cemile.bathelt@usb.ch
+41 61 556 54 07
Time Frame
Start Date: 2025-04-14
Estimated Completion Date: 2027-04
Participants
Target number of participants: 70
Treatments
Experimental: Protein Supplementation
80 g protein supplementation per day (two bottles, each containing 40 g protein)
Active_comparator: Fluid restriction
total daily fluid intake to a maximum of 1000 ml
Related Therapeutic Areas
Sponsors
Leads: University Hospital, Basel, Switzerland