Lung Adenocarcinoma Clinical Trials

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A Prospective Clinical Trial of Tumor Immunomodulation Using Tumor-Treating Fields (TTFields) in Patients With Early-Stage Resectable Lung Adenocarcinoma

Status: Recruiting
Location: See all (7) locations...
Intervention Type: Device
Study Type: Interventional
Study Phase: Phase 1
SUMMARY

The researchers are doing this study to find out if treatment with TTFields using the NovoTTF-200T System is safe and practical (feasible) before surgical removal (resection) of lung adenocarcinoma (ADC). The researchers will also look at how the treatment may help the body's immune system to fight cancer.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 22
Healthy Volunteers: f
View:

• The participant (or legally acceptable representative \[LAR\], if applicable) provides written informed consent for the study.

• The participant is ≥22 years of age on the day of signing informed consent.

• The participant has clinical stage 1A2, 1A3 or IB biopsy-proven lung ADC and is eligible for anatomical resection.

• The participant has a lung nodule \>1 cm and suspected lung ADC with a plan to undergo biopsy.

• The participant with multiple nodules has one nodule that meets the criteria.

• The participant has no history of prior malignancy in the chest or has undergone potentially curative therapy with no evidence of that disease recurrence for 5 years since initiation of that therapy.

Locations
United States
New Jersey
Memorial Sloan Kettering Basking Ridge (Consent Only)
RECRUITING
Basking Ridge
Memorial Sloan Kettering Monmouth (Consent Only)
RECRUITING
Middletown
Memorial Sloan Kettering Bergen (Consent Only)
RECRUITING
Montvale
New York
Memorial Sloan Kettering Suffolk - Commack (Consent Only)
RECRUITING
Commack
Memorial Sloan Kettering Westchester (Consent Only)
RECRUITING
Harrison
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
RECRUITING
New York
Memorial Sloan Kettering Nassau (Consent Only)
RECRUITING
Uniondale
Contact Information
Primary
Prasad Adusumilli, MD
adusumip@mskcc.org
212-639-8093
Backup
Matthew Bott, MD
212-639-5944
Time Frame
Start Date: 2023-08-04
Estimated Completion Date: 2027-08
Participants
Target number of participants: 25
Treatments
Experimental: NovoTTF-200T System Tumor-Treating Fields (TTFields)
Following pathological confirmation on of lung ADC, patients will proceed with TTFields treatment. The NovoTTF-200T System is an investigational medical device delivering 150 kHz TTFields to the patient's chest. The device is applied continuously for an average duration of 18 hours per day for 3 weeks (+/- 1 week).
Related Therapeutic Areas
Sponsors
Leads: Memorial Sloan Kettering Cancer Center
Collaborators: NovoCure Ltd.

This content was sourced from clinicaltrials.gov