Cancer Hospital Chinese Academy of Medical Sciences
Current clinical follow-up frequency and treatment timing for pulmonary subsolid nodules (SSNs) rely mostly on whether the nodules grow, which may not accurately reflect the pathological status, and may lead to unnecessary follow-ups. This study aims to use multi-omics techniques to dynamically observe the growth and invasiveness evolution process of SSNs and uncover its invasiveness mechanism. Radiological characteristics of SSNs in different invasiveness stages were also analyzed and summarized by analyzing preoperative CT. This can overcome the bottleneck of invasiveness assessment in the growth process of SSN and provide scientific evidence for the scientific management and clinical treatment timing choice of SSN patients, thus facilitating the rational allocation of medical resources and prolonging the expected survival of national health.
⁃ Patients with SSNs
• Newly diagnosed patients with persistent SSNs confirmed by thin-section chest CT examination
• Patient areilling to undergo surgery
• Voluntarily sign a written informed consent form
⁃ Healthy Volunteers
• Healthy volunteers aged 18-50 years, regardless of gender.
• No lung nodules detected on chest thin-section CT.
• No history of cancer.
• Voluntary sign a written informed consent form.