Low-glucose/High-fat Intake Dietary Regimen as a Tool for Empowering Diagnostic Accuracy of 2-[18F]FDG PET/CT in Lepidic-predominant Growth Lung Adenocarcinoma
This study evaluates whether a 7-day ketogenic dietary regimen before 2-\[18F\]FDG PET/CT can improve the diagnostic accuracy of imaging in adults with suspected or histologically confirmed lepidic-predominant lung adenocarcinoma (LPA). LPA frequently shows low glucose metabolism and may yield false-negative FDG PET/CT results. Approximately 30 participants will undergo a tailored ketogenic diet for 7 days before PET/CT. Imaging results will be compared with histopathology and additionally assessed against literature-reported diagnostic performance and a matched retrospective institutional cohort.
• Written informed consent.
• Age 18 years or older.
• CT evidence of a lung nodule suspicious for LPA or lung biopsy positive for LPA.
• Target nodule diameter at least 10 mm.
• ECOG performance status 0 to 2.
• Willingness and ability to adhere to a controlled ketogenic diet for 7 days.
• Ability to comply with study procedures and visit schedule.