Impact of Intraoperative Blood Pressure Management and Dexamethasone on Patient's Outcomes After Lung Cancer Surgery: A 2 × 2 Factorial Randomized Controlled Trial

Status: Recruiting
Location: See location...
Intervention Type: Other, Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Surgery is the front-line therapy for non-small cell lung cancer (NSCLC) but postoperative complications remains high and patients' long-term outcome is still challenging. In addition to surgery, anesthetic management particularly intraoperative blood pressure management and use of dexamethasone may affect patients' early and long-term outcomes after surgery for NSCLC. This study aims to investigate the impact of intraoperative blood pressure management and dexamethasone administration on early and long-term outcomes in patients undergoing surgery for lung cancer.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 50
Maximum Age: 90
Healthy Volunteers: f
View:

• Aged \>50 years but \<90 years.

• Diagnosed as resectable primary non-small cell lung cancer (stage IA-IIIA) and scheduled for radical surgery with an expected duration of \>2 hours.

• Agree to participate in this study and sign the informed consent.

Locations
Other Locations
China
Department of Anesthesiology and Critical Care Medicine, Peking University First Hospital
RECRUITING
Beijing
Contact Information
Primary
Dong-Xin Wang, MD, PhD
wangdongxin@hotmail.com
86 (10) 83572784
Backup
Wen-Wen Huang, MD
hww9215@163.com
86 (10) 83572460
Time Frame
Start Date: 2020-04-07
Estimated Completion Date: 2029-12
Participants
Target number of participants: 1988
Treatments
Placebo_comparator: Routine blood pressure management + placebo
Blood pressure is maintained according to routine practice. Placebo (normal saline 2 ml) is administered before anesthesia induction.
Experimental: Routine blood pressure management + dexamethasone
Blood pressure is maintained according to routine practice. Dexamethasone (10 mg/2 ml) ia administered before anesthesia induction.
Experimental: Targeted blood pressure management + placebo
Blood pressure is maintained within ±10% from baseline. Placebo (normal saline 2 ml) is administered before anesthesia induction.
Experimental: Targeted blood pressure management + dexamethasone
Blood pressure is maintained within ±10% from baseline. Dexamethasone (10 mg/2 ml) is administered before anesthesia induction.
Sponsors
Leads: Peking University First Hospital

This content was sourced from clinicaltrials.gov