Comparison of Segmentectomy Versus Lobectomy for Early-stage Non-small Cell Lung Cancer ≤ 2 cm in the Middle Third of the Lung Field: A Prospective and Multi-center RCT Study
This study aims to investigate whether segmentectomy had non-inferiority long-term oncological effects (disease-free survival and overall survival) compared with lobectomy in the treatment of patients with early-stage non-small cell lung cancer ≤ 2 cm in the middle third of lung field.
• Patient aged 18-75 years old;
• 6 mm ≤ tumor size ≤ 20 mm;
• 0.25 \< CTR \< 1;
• Center of tumor located in the middle third of the lung field;
• ECOG score of 0,1 or 2;
• Lung function (FEV1 ≥ 1 L and ≥ 70%);
• Both lung segmentectomy and lobectomy could achieve R0 resection;
• No serious cardiopulmonary complications, and could withstand both lung segmentectomy and lobectomy;
• No hilus pulmonis and mediastinal lymph node metastasis and no distant metastasis;
⁃ Single tumor nodule or the concomitant nodule \< microinvasive tumor;
⁃ Written informed consent.