Improving Response Assessment in Cancer by Measurement of Cellular Redox Status Using 18F-FSPG Positron Emission Tomography
Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY
Prospective single centre non-randomised exploratory observational study to measure changes in tumour cellular redox status with 18F-FSPG PET in stage 3 non-small cell lung cancer (NSCLC) and stage 3 and 4 head and neck squamous cell cancer (HNSCC) at baseline and during standard of care treatment, and to compare this with 18F-FDG PET/CT and RECIST 1.1 response at 12 weeks.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 16
Healthy Volunteers: f
View:
• Written informed consent
• Aged 16 or above
• Histologically confirmed HNSCC or NSCLC, who are treatment naïve and scheduled to commence standard of care treatment ((chemo)radiotherapy)
• Willingness and ability to comply with scheduled study visits and tests
• Confirmation of adequate function of all major organs and systems
Locations
Other Locations
United Kingdom
Guy's and St Thomas' NHS Foundation Trust
RECRUITING
London
Contact Information
Primary
Gark Cook
gary.cook@kcl.ac.uk
0207 188 8364
Time Frame
Start Date: 2025-02-19
Estimated Completion Date: 2027-09
Participants
Target number of participants: 32
Treatments
Non-small cell lung cancer
NSCLC
Head and neck squamous cell cancer
HNSCC
Related Therapeutic Areas
Sponsors
Leads: Guy's and St Thomas' NHS Foundation Trust
Collaborators: King's College London