Characterization of Microbiota (intestinal, from Lungs, and Upper Airways) in Patients with Non-small Cell Lung Carcinoma: Exploratory Study
Who is this study for? Patients with non small cell lung cancer
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The subject is to study the lung microbiota and the one of upper airways (UAs) (much less studied than the intestinal microbiota) in 40 patients having lung cancer. 20 patients undergo only surgical treatment, while other half receives also chemotherapy. The idea is to explore changes in microbiota of the lung, upper UAs and intestine, and potentially find associations between them. These results will serve us as a base for the future study, focused on manipulation of the microbiota by prebiotics, probiotics or symbiotics and its effect on anti-cancer treatment tolerance and effectiveness.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:
• non small cell lung carcinoma patient suitable for surgery, or chemotherapy followed by surgery
• BMI \<29.9 kg/m²
• not taking antibiotics, corticosteroids and/or immunosuppressants at least during two months before inclusion
• not taking prebiotics, probiotics or symbiotics at least during two months before inclusion
• signing the written consent before enrollment in the study
• affiliation to the national health insurance (or system alike) according to the law from 9th August 2004
Locations
Other Locations
France
Centre Jean Perrin
RECRUITING
Clermont-ferrand
Contact Information
Primary
Marc Filaire, MD, Pr
marc.filaire@clermont.unicancer.fr
0473278121
Time Frame
Start Date:2017-05-23
Estimated Completion Date:2029-10-30
Participants
Target number of participants:40
Treatments
Experimental: Pchir
Non small cell lung carcinoma patients designated for immediate surgery. Intervention in this group is sampling. The sampling will be done for:~* blood and saliva: at consultations after inclusion in the study~* faeces: day before the surgery~* lung/tumour tissue, bronchoalveolar lavage: during surgery after lobectomy
Experimental: Pct-chir
Non small cell lung carcinoma patients who will receive neoadjuvant chemotherapy before the surgery. Intervention in this group is sampling. The sampling will be done for:~* blood and saliva: 1st time at consultations after inclusion in the study, 2nd time at consultations after chemotherapy and before surgery~* faeces: 1st time the day before the chemotherapy, 2nd time the day before the surgery~* lung/tumour tissue, bronchoalveolar lavage: during surgery after lobectomy