IFN-y PET Imaging: Bench to Bedside
The goal of this clinical trial is to investigate the use of \[89Zr\]Zr-DFO-emapalumab as an IFN-γ PET imaging agent to detect lesions and response to therapy among treatment-naïve non-small cell lung cancer (NSCLC) patients. PET scans following the imaging agent will be completed prior to and about 30 days after starting immunotherapy.
• Prior histologic or cytologic diagnosis of non-small cell lung cancer.
• FDG PET done within 2 months of the baseline imaging, as part of standard-of-care.
• measurable disease by RECIST 1.1 with at least one lesion of at least 2 cm in a region of the body that can be imaged by PET (e.g.,outside of the liver)
• must be able to lie still for the tests. Their girth and weight must be suitable to enter the gantry, which varies per tomograph.
• must be \>18 years old.
• Patients must sign an informed consent indicating that they are aware of the investigational nature of this study, in keeping with the policies of the cancer center.
• Physical exam, CBC and Multiphasic (including electrolytes, BUN, creatinine, total bilirubin, AST, and ALT) must be done within 28 days prior to PET imaging