Comparative Analysis of Minimally Invasive and Open Sleeve Lobectomy Following Neoadjuvant Therapy in NSCLC: A Multicenter Retrospective Evaluation of Surgical Outcomes

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

The goal of this observational, retrospective, multicenter cohort study is to evaluate the surgical and oncologic outcomes of sleeve lobectomy performed via minimally invasive (RATS/VATS) or open thoracotomy approaches in patients with non-small cell lung cancer (NSCLC) who have undergone neoadjuvant therapy, including chemotherapy, immunotherapy, or combination regimens. The main questions this study aims to answer are: * Does minimally invasive sleeve lobectomy result in comparable or improved perioperative and postoperative outcomes compared to open thoracotomy following neoadjuvant treatment in NSCLC? * Does surgical approach influence oncologic endpoints such as margin status, lymph node dissection, recurrence-free survival, and overall survival? This research addresses a critical gap in the thoracic oncology field by evaluating the safety, complexity, and efficacy of advanced surgical techniques in the context of evolving multimodal therapy paradigm. Findings may inform clinical decision-making and optimize patient selection in an era of increasing use of neoadjuvant strategies for resectable NSCLC.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age ≥ 18 years

• Histologically confirmed NSCLC

• Undergoing sleeve lobectomy with curative intent

• Receipt of neoadjuvant therapy (chemotherapy, immunotherapy, target therapy, etc.)

• Surgical approach: either minimally invasive (VATS or RATS) or open thoracotomy

• Availability of complete perioperative and follow-up data (minimum 12-month follow-up or until death)

• Signed informative consent

Locations
Other Locations
China
Shanghai Chest Hospital
RECRUITING
Shanghai
Contact Information
Primary
Xinghua Cheng, M.D., Ph.D.
chengxinghua_001@163.com
86+17701681215
Backup
Zhebing Lin, M.D.
lzb0315@sjtu.edu.cn
86+18957727196
Time Frame
Start Date: 2025-09-01
Estimated Completion Date: 2025-12-01
Participants
Target number of participants: 400
Treatments
Thoracotomy sleeve lobectomy
Patients who underwent open sleeve lobectomy following neoadjuvant therapy
MIS sleeve lobectomy
Patients who underwent minimally invasive (i.e. VATS and RATS) sleeve lobectomy following neoadjuvant therapy
Sponsors
Collaborators: Second Affiliated Hospital, School of Medicine, Zhejiang University, University of Padova, Padova, Italy, Sir Run Run Shaw Hospital
Leads: Shanghai Chest Hospital

This content was sourced from clinicaltrials.gov