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Exercise as Maintenance Therapy in Advanced Lung Cancer

Status: Recruiting
Location: See all (3) locations...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The purpose of this study is to examine how a multimodality (having or using a variety of methods to do something) exercise intervention may improve survival, function, and quality of life in participants with advanced lung cancer.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age ≥ 18 years

• Known diagnosis of locally advanced (stage III) or metastatic NSCLC

• Patient is currently receiving maintenance immunotherapy for at least 1 month and planned for at least 3 additional months of therapy

‣ Patients receiving maintenance therapy refers to patients with stable disease or partial response to therapy, including patients who have had a history of disease progression but are currently stable or responding to a different therapy

⁃ Patients previously receiving chemotherapy are eligible as long as at least one month has elapsed since completing chemotherapy. Those currently receiving chemotherapy are not eligible.

• Patient is willing and able to participate in a supervised home-based exercise program as determined by the MOVE program

• a.Participants must have internet access and equipment to participate in virtual exercise

• ECOG performance status of 0-2

Locations
United States
Indiana
Indiana University Health Methodist Hospital
RECRUITING
Indianapolis
Indiana University Melvin & Bren Simon Comprehensive Cancer Center
RECRUITING
Indianapolis
Sidney and Lois Eskenazi Hospital
RECRUITING
Indianapolis
Contact Information
Primary
Malori Pojar
mpojar@iu.edu
(317) 274-0930
Backup
Tarah J Ballinger, MD
tarahb@iu.edu
Time Frame
Start Date: 2024-10-15
Estimated Completion Date: 2029-12
Participants
Target number of participants: 100
Treatments
Experimental: Exercise Intervention
Eligible and consented participants randomized to the exercise arm will work with an exercise trainer three times weekly for 12 weeks. Training sessions will be delivered virtually using HIPPA Complaint IU Health Zoom. These sessions will last 60 minutes and include cardiovascular exercise, resistance training, and balance or stretching exercise. The participants will be able to use any equipment they already have at home but will be provided a heart monitor and a set of resistance bands.~All sessions will have a moderate-intensity training goal, defined as 40-80% of heart rate reserve (HRR). Cardiovascular exercise will include any at-home equipment available to the participants or follow a Tabata-style program. Resistance training will include a full body workout, emphasizing all major muscle groups. Trainers will progress or regress intensity levels based on the participant's rate of perceived exertion (RPE), heart rate, and individual response during each session.
No_intervention: Usual Care
Participants randomized to usual care arm will receive care per their treatment team. Usual care participants are encouraged to exercise but will not be provided components of the intervention. Participants in the usual care arm will be given usual care handouts at baseline.
Sponsors
Leads: Indiana University

This content was sourced from clinicaltrials.gov

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