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LUMEN-Dx: Novel Epigenetic Mapping in Cell-Free DNA for the Detection of Lung Cancer

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

This trial is a multicenter, open-label, non-interventional controlled study to identify and characterize epigenetic signatures of lung cancer. The goal of this study is to develop a simple blood test that can detect lung cancer with high sensitivity, and assist in the early diagnosis and management of lung cancer. In particular, the ability to assist existing methods in cancer diagnostics, predict response to treatment, and assess the success of treatment during and after treatment will be examined. In addition, the ability to assess minimal residual disease (MRD) will be evaluated, by taking blood after surgery to remove a tumor or after treatment, and testing whether there is any residual DNA from the tumor using the markers that are found. The collection of patients and data will be conducted over a period of about a year and a half, with the aim of reaching approximately 300 participants, including patients with lung cancer before and after treatment/surgery and control groups.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:

• Men and women over 18 years old.

• Patients diagnosed with lung cancer before systemic therapy.

• Patients with inconclusive LDCT findings.

• Healthy volunteers.

• Patients with chronic lung diseases (COPD, pulmonary emphysema, acute pneumonia).

Locations
Other Locations
Israel
Sheba Medical Center
RECRUITING
Ramat Gan
Contact Information
Primary
Yael Michaeli, Ph.D.
yaelmi@jaxbio.com
Time Frame
Start Date: 2025-05
Estimated Completion Date: 2026-11
Participants
Target number of participants: 300
Treatments
Lung cancer patients
lung cancer patients will be recruited at diagnosis. Blood will be taken before surgery / treatment and after surgery / treatment at the indicated time points.
non-malignant lung disease
Non-malignant lung disease cohort includes patients with chronic lung disease such as COPD, or acute pneumonia, and will serve as a control group to identify lung cancer and distinguish it from other lung diseases.
Healthy controls
Healthy individuals will serve as a control group.
Related Therapeutic Areas
Sponsors
Leads: JaxBio Ltd

This content was sourced from clinicaltrials.gov