A Prospective, Multicenter, Umbrella Design Clinical Study on the Abscopal Effect Induced by Different Radioimmunotherapy Combination Patterns in the Treatment of Non-Small Cell Lung Cancer With Multiple Metastases
It is planned to carry out a multicenter umbrella study to find the optimal organ combination and the best radioimmunotherapy combination pattern, so as to improve the survival of NSCLC patients with multiple metastases. At the same time, by using multimodal omics data, machine learning will be employed to construct a prediction model for the abscopal effect, and explore the immunoregulation of organ-specific radiotherapy and biomarkers of the abscopal effect. The main objective is to find the optimal organ combination and the best radioimmunotherapy combination pattern.
• Patient must meet all of the following inclusion criteria to be enrolled in this study:
‣ Non-small cell lung cancer diagnosed initially through pathological histology.
⁃ There are 3-6 metastatic lesions.
⁃ No brain metastasis or the lesions are stable.
⁃ Negative for driver genes (including EGFR, ALK, ROS, BRAF, MET, RET genes. Note: The above English terms are all gene names).
⁃ ECOG (Eastern Cooperative Oncology Group) score: 0-1 point, with an expected, survival period of more than 3 months.
⁃ Aged between 18 and 75 years old.
⁃ Evaluated by PET-CT (including FDG and FMISO, not mandatory).
⁃ No contraindications for immunotherapy and radiotherapy.
⁃ The informed consent form has been signed.